Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral (...) NS3/4A protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

This book's importance is derived from three sources: careful conceptualization of teacher induction from historical, methodological, and international perspectives; systematic reviews of research literature relevant to various aspects of teacher induction including its social, cultural, and political contexts, program components and forms, and the range of its effects; substantial empirical studies on the important issues of teacher induction with different kinds of methodologies that exemplify future directions and approaches to the research in teacher induction.

ORTSBESTIMMUNG DER PHILOSOPHISCHEN GRAMMATIK I. Absicht dieser Arbeit ist es, ein wenig Licht in die teils komischen, teils lebensgefährlichen Aspekte der Aufsplitterung unseres Lebens in h eines vor und in eines nach I7 zu bringen, und zwar anhand des Ent­ wicklungsgangs der Wittgensteinschen Philosophischen Grammatik. Das aufgezeigte Problem kursiert unter vielen Titeln und Etiketten: Theorie und Praxis, Wissen und Glauben, Beruf und Freizeit o. ä. Diese Auf­ zählungen möchten allerdings kein Unvermögen des Verfassers andeuten, sich auf einen Titel festzulegen. Vielmehr (...) ist es ein wichtiges Resultat Wittgensteinschen Philosophierens, dass verschiedene Sinne nicht selbiges vermeinen, insofern sie denselben Gegenstand meinen, sondern sofern sich der Sinn als Sinn durchhält, d. i. als Gebrauch im Umlauf ist. Insofern der Verfasser mit Wittgenstein die Partikel »d. h. «, »d. i. «, »m. a. W. « und ähnliche für das Philosophieren für konstitutiv und eigentümlich hält, also, mithin die Bestimmung »Sinn ist Sinn als Sinn«! zu erfüllen ver­ sucht (trotz der penetranten Häufung in einer derartigen Exposition), können die Untersuchungen zunächst als »subjektiv«, bzw. »transzen­ dental« bezeichnet werden. Die nähere Lokalisierung des Themas wird in drei Zügen vorgenommen: das populäre Gegensatzpaar »Ideologie« lmd »Wissenschaft« führt uns zu den in einer bestimmten philosophischen Tradition fixierten Begriffen »Lebenswelt« und »technische Welt«, deren Widerstreit wiederum von L. Eley auf das ungeklärte Verhältnis von Phänomenologie und Logik zurückgeführt worden ist. Nach dieser Orts­ bestimmung wird hoffentlich einigermassen verständlich, dass die Kenn­ zeichnung Wittgensteins als eines Aufklärers nicht nur nicht logische Untersuchungen verbietet, sondern sie vielmehr notwendig macht. (shrink)

Originally published in 1936 as part of the 'Medieval Epics' series for Cambridge Contact Readers, this book contains the stories of the folk heroes Dietrich von Bern and Tannhäuser in German. The text is illustrated with beautiful black and white drawings, and a vocabulary list is provided at the end of the volume. This book will be of value to anyone with an interest in German folklore or the history of German education in Britain.

This paper will survey and assess the ways in which moral thinkers in the early modern tradition of casuistry considered a range of cases of conscience (casus conscientiae) relating to lying, deception, and witholding the truth. Arguing that the position of the casuists has been unjustly maligned — not least by Pascal's brillant yet partizan Les Proviniciales — casuistical theories of lying and simulation will be placed in a broad intellectual context which will examine attihules to mendacity among early modern (...) medical writers, political theorists, anbl philosophers. Contrasting casuistical theoriessuch as equivocation and mental reservation with the approach to lying of other early modern writers, the lecture will advancfcahe view that the casuists promulgated a conceptual outlook on the differences betweefc lying and deception which is of inherent interest, and which helps to clarify some of the salient issues that attend a philosophical account of lying. (shrink)